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Connecting the dots: Exploring backdoor attacks on graph neural networks
Deep Neural Networks (DNNs) have found extensive applications across diverse fields, such as image classification, speech recognition, and natural language processing. However, their susceptibility to various adversarial attacks, notably the backdoor attack, has repeatedly been demonstrated in recent years. <br/>The backdoor attack aims to...
doctoral thesis 2025
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Is this network proper forest-based?
In evolutionary biology, networks are becoming increasingly used to represent evolutionary histories for species that have undergone non-treelike or reticulate evolution. Such networks are essentially directed acyclic graphs with a leaf set that corresponds to a collection of species, and in which non-leaf vertices with indegree 1 correspond...
journal article 2025
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Exploring a new dimension: Single-molecule interaction studies in sequence space
Interactions are essential to life. At the cellular level, the most fundamental processes rely on interactions between DNA, RNA, and proteins. Given that the structure and function of these molecules are determined by their sequence, it is ultimately the sequence that dictates the strength and specificity of these interactions. Thus, to improve...
doctoral thesis 2024
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Transient Hydraulic Transport in Pipelines: On flow assurance influenced by slurry dynamics
Hydraulic transport pipelines are used in dredging, (wet) mining and deep sea mining. These pump-pipeline systems are typically designed using steady-state principles. However, recent cases have shown that steady-state design does not always guarantee stable pipelines. Transients like self-amplifying density waves have shown to be able to...
doctoral thesis 2024
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The relationship between geometric and mechanical properties of shell structures
Shell structures can be either calculated with complex mathematics and differential geometry, or with the help of finite element method (FEM) software. Neither method gives the designer sufficient insight about the behaviour of the shell in the early design stage. The first method is for most designers too complex, it requires proficiency in at...
doctoral thesis 2024
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VHF Magnetic and Electric Sensors for Partial Discharge Measurements in GIS
The energy transition towards decarbonization and modernization of the electric network requires the development of new technologies. Offshore windfarms, essential to this transition, rely on Gas-Insulated Systems (GIS) due to their compactness and extended lifespan. Despite the reliability of GIS, the high maintenance costs and severe...
doctoral thesis 2024
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Ultrasound transducers for ultrafast 3D cardiovascular imaging
Cardiovascular diseases stand as the leading cause of death worldwide. Cardiovascular diseases are a group of disorders of the heart and blood vessels, such as atherosclerosis, congenital heart diseases, rheumatic heart diseases, and arrhythmias. Early detection of cardiovascular issues is imperative for effective treatment, and the...
doctoral thesis 2024
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Black Scintillators: Exploring Sm2+ as a near-infrared emitting activator for gamma-ray spectroscopy
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Distributing quantum information with holes in germanium
In this thesis, research is presented that explores the characteristics and possibilities of hole spin qubits defined in quantum dots in a germanium/silicon germanium heterostructure. The results of the most important experiments are concerned with distributing quantum information: either by entangling three qubits as the basis for the phase...
doctoral thesis 2024
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Binary Deep Learning: Binary Weights and Semantic Binary Data Compression
Improving the efficiency in deploying deep neural networks (DNNs) and processing complex high-dimensional data has drawn increasing attention in recent years. Yet, the deployment of large DNN models is challenged by the high computational complexity and energy consumption, making it difficult to run on resource-constrained devices such as mobile...
doctoral thesis 2024
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Contemporary Conflicts and Crises: A mathematical approach
In this thesis, we use mathematical models to assist the Dutch Ministry of Defence with understanding and decision-making within contemporary conflicts and crises. We explore ways to reduce the spread of COVID-19, study dynamics in the Sino-Indian border dispute, and investigate the value of scouting in conflicts involving autonomous systems. ...
doctoral thesis 2024
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Irrigation technology at the service of smallholder farmers: A sociotechnical approach to exploring sustainable business strategies
Recently, there has been a growing need for sustainable agriculture to increase food security, alleviate poverty, and contribute to climate change mitigation. Smallholder farmers (SFs) play a key role in this endeavor as they are a considerable segment of the global farming population. Despite their relevance, SFs face several challenges that...
doctoral thesis 2024
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Electron Beam-Induced Fluorescence Localization: Implementation and Feasibility in Integrated Light-Electron Microscopy
Correlative light-electron microscopy (CLEM) combines the molecular specificity of fluorescence microscopy (FM) with the ultrastructural resolution of electron microscopy (EM) to provide functional information in the context of structural detail. However, the correlation between the two modalities is hindered by a 100-fold resolution gap....
doctoral thesis 2024
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Spatiotemporally Resolved Corrosion Inhibition Studies of Lithium Salts for Aerospace Aluminium Alloys
Over many decades, intensive studies have been performed towards safe and sustainable substitutes for chromate corrosion inhibitors in active corrosion protection coatings for aerospace aluminium alloys. The proposed candidates must provide similar corrosion protection as compared to that of chromate-based compounds and be cost-effective for...
doctoral thesis 2024
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Exploring SMC motor proteins and how to stop them
Genetic information encoded in the DNA sequences is maintained, replicated, and transcribed across the tree of life. Organisms evolved multiple hierarchical layers of chromosome organization which ensure that DNA can be contained but also processed within individual cells. This thesis focuses on SMC (Structural Maintenance of Chromosomes)...
doctoral thesis 2024
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Continuous downstream processing
The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity...
review 2024
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This thesis explores the ethical challenges that a potential research program for solar climate engineering via Stratospheric Aerosol Injection (SAI) could incur. These ethical challenges are comprised of epistemic hurdles in relation to the research process, as well as societal questions of justice and the value of nature. The thesis proposes a...
doctoral thesis 2024
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Single-molecule studies of fully reconstituted CMG
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More Effective Test Case Generation with Multiple Tribes of AI
Software testing is important to make sure that code works as intended. Traditionally, this verification process has relied on manual testing, which is not only time-consuming but also susceptible to human errors. Through the use of automated test case generation techniques, we can automate this process and reduce the time and effort needed to...
doctoral thesis 2024
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Embedded analytical-numerical simulation of fault reactivation in heterogeneous subsurface formations: Inspired by the issue of induced seismicity in the Groningen field
Induced seismicity refers to seismic events (earthquakes) triggered by human activities. Such events, even when characterized by relatively modest magnitudes, have the potential to jeopardize the safety of individuals, the surrounding environment, and infrastructure. <br/><br/>Production from hydrocarbon reservoirs can alter the in-situ stress...
doctoral thesis 2024